Ultra Flora Immune Control 60 VegeCaps- Metagenics

A Probiotic Combination For Healthy Immune System Function

Probiotic strains in Ultra Flora Immune Control have been shown to help:

• Maintain healthy immune system regulation.
• Reduce occurrence of, and manage, allergy symptoms.
• Combination of two immune modulating, anti-inflammatory probiotic strains.

Clinical Benefits

• Regulate the immune system: Lactobacillus rhamnosus LGG® and lactobacillus paracasei (LP-33®) help to promote immune regulation by interacting with dendritic cells within the gut associated lymphoid tissue (GALT) stimulating the production of regulatory T cells and increasing production of regulatory cytokines such as IL-10 and TGF-beta. LGG® also promotes a shift towards an enhanced anti-inflammatory response by a heightened secretion of anti-inflammatory cytokines and decreased secretion of pro-inflammatory cytokines.
• LGG® has bidirectional immunomodulatory effects - stimulatory when an increased response is needed and down-regulatory when attenuation is appropriate. 20 billion CFU of LGG® daily has been shown to reduce immune hyper-reactivity by strengthening gut mucosal barrier integrity.
• LP-33® modulates inflammation and immune reactions by interacting with these cells and, together with LGG®, inducing development of regulatory T cells which can down regulate IgE, a Th2 cytokine involved in allergy. A double-blind, randomised, placebo-controlled trial on 425 subjects with allergic rhinitis compared the effects of LP-33® or placebo over a five week period. The LP-33® group demonstrated significant improvements in their Rhinitis Quality Of Life (RQLQ) score, nasal and ocular symptoms (Figure One).

Figure 1: Lactobacillus paracasei (LP-33®) Improves Symptoms of Allergic Rhinitis.Costa DJ, Marteau P, Amouyal M, Poulsen LK, Hamelmann E, Cazaubiel M, et al. Efficacy and safety of the probiotic Lactobacillus paracasei LP-33 in allergic rhinitis: a double-blind, randomized, placebo-controlled trial (GA2LEN Study). Eur J Clin Nutr. 2014 May;68(5):602-7. 2014.

LGG® is a registered trademark of Chr. Hansen A/S.

Directions

Directions for use (adults and adolescents):
To support immune system function: Take one capsule daily.
To reduce symptoms of mild allergies: Take one capsule twice daily.

Store at 2°C to 8°C. (Refrigerate. Do not freeze.)

Warnings

As a precaution: Safety has not been conclusively established during pregnancy. Practitioner discretion is advised when prescribing for use in pregnancy due to the following cautions:

Pre-eclampsia: A meta-analysis of four clinical trials shows that taking probiotics during pregnancy increases the relative risk of pre-eclampsia.

The specific effects of Lactobacillus rhamnosus (LGG®) are unclear from this analysis.

Vegetable capsules (VegeCaps) may be preferred by people wishing to avoid gelatin for health or religious reasons. Not all cautions and contraindications are listed.