Ultra Flora LGG® 60 Capsules- Metagenics

Researched, Authentic LGG®.

• For a wide range of microbiome clinical protocols and for immune conditions and gastrointestinal function.
• Contains the authentic LGG® strain and supply chain, with over 20 years of clinical research.
• No refrigeration required - remains full strength for the length of shelf life (when stored below 25°C), for improved patient compliance.
• Dairy free.

Clinical Benefits:

LGG® is one of the world’s most researched probiotic strains with 1000+ scientific publications and over 300 in humans. Isolated by Gorbach and Goldin in 1985, LGG® has unique hair-like appendages called pili which increase its persistence in the gastrointestinal tract where it is able to exert positive health benefits. A direct comparison of commercialised GG probiotics (against LGG®) showed major DNA segments to be missing with pili encoding genes among these. Manufacturing and growth mediums can also effect both the genetic expression and survival of pili. Metagenics have exclusively used trademarked LGG® since 2008, guaranteeing strain and manufacturing authenticity, and matching the majority of human clinical trials.

Figure 1: LGG® with Pili (Hair-Like Appendages) to Maximise Mucosal Adhesion.

Immunological Use: LGG® is immune modulating with the lower dose range (1 billion – 10 billion CFU) supporting immune response and has been shown to reduce upper respiratory tract infections (URTIs) and colds (particularly in children).

Allergy: Higher doses of LGG®(20 billion CFU ) have been shown to up regulate anti-inflammatory interleukins (IL-10) and down regulate ImmunoglobulinE (IgE) synthesis. In addition to a significant amount of research in infants and prenatally, a 2015 clinical trial showed a reduction in peanut allergy in children when used in conjunction with a desensitisation program. Metagenics supports Professor Mimi Tang’s research in childhood food allergy at the Murdoch Children’s Research Institute and are product suppliers for a follow-up study in peanut allergy.

Gastrointestinal Use: Diarrhoea:LGG® (10-20 billion CFU) reduces the frequency, severity and duration of diarrhoea – viral, travellers and also antibiotic associated.

Microbiome Use: Regeneration of core commensal (native) gut flora: More recently DNA sequencing of the microbiome has shown LGG® has the ability to influence and regenerate commensal bacterial families.

Prenatal Use: LGG® has a wide body of evidence showing reduced allergy, eczema and atopy when taken prenatally. More recent research has shown support for maternal glucose control, maternal and childhood obesity and reduced incidence of childhood behavioural complaints (when taken during pregnancy and infancy).

Figure 2: LGG® Mucus Adhesion v GG Mutants.

Always read the label. Follow the directions for use. If symptoms persist, consult your healthcare professional.

Directions:

Adults: Take 2 capsules daily.

To maintain healthy gut flora: Take 1 capsule daily.

Warnings:

As a precaution: Safety has not been conclusively established during pregnancy. Practitioner discretion is advised when prescribing for use in pregnancy due to the following cautions:

Pre-eclampsia: A meta-analysis of four clinical trials shows that taking probiotics during pregnancy increases the relative risk of pre-eclampsia.

The specific effects of Lactobacillus rhamnosus (LGG®) are unclear from this analysis.

Vegetable capsules (VegeCaps) may be preferred by people wishing to avoid gelatin for health or religious reasons. 

Storage:

Store at 25°C. Activ-Vial™ desiccant lined bottle protects probiotics so they stay live and effective without refrigeration.